Rethymno is connected to Pireaus with daily itineraries of ships through Heraklio and Chania. Chania is 45 minutes driving distance and Heraklio is 1 hour driving distance. Rethymno is located close to the center of Crete thus making accessible some of the most important sights in Crete such as Knossos, Phaistos and Samaria gorge. There is a frequent bus connection to Heraklio and Chania from Akti Kefalogianniton every half hour until the evening. If you would like to be more independed we strongly recommend renting a car as rents can be as low as 30 Euro per day and it is a nice way to move around and see what the island has to offer.